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Annex B 1 to Doc. NS0014B2 SSC 15 Jan. 2000 ; Ganstigmine Gemifloxacin Ibritumomab tiuxetan Idremcinal Ilodecakin Izonsteride Lasofoxifene Liatermin Licarbazepine Mepolizumab Olanexidine Pibrozelesin Pimecrolimus Prazarelix Ranpirnase Rasburicase Rovelizumab Sarakalim Selamectin 2934.90 2933.90 3002.10 [2932.29] [2932.99] [2940.00] 3002.10 To be studied further as to whether it is a product of heading 29.40 or a lactone of heading 29.32.

Tant factors involved in the process of producing contraction are differentially expressed in the pregnant and non-pregnant myometrium, such as G-protein-coupled receptor kinases [1], ryanodine-sensitive Ca2 + release channels [10]. So the mechanism of erythromycin-primed contractions in pregnant and non-pregnant uterine smooth muscle is worth to study further. In summary, the findings of our study indicate that erythromycin increased the contractile frequency and tension in uterine smooth muscle in non-pregnant rats. The frequency and tension increase could be induced through histamine H1 receptor and calcium channel. Further in vivo studies of erythromycin influence on uterine activity in rats and in vitro research on human myometrium will allow us to gain new insights into the effect of erythromycin on uterus. The inhibition of topoisomerase IV from S. pneumoniae C3LN4 by ciprofloxacin and gemifloxacin is shown in Figure 1. From these plots IC50 values were calculated, and gemifloxacin was found to be approximately five times as active as ciprofloxacin. The results for inhibition of DNA gyrase from S. pneumoniae C3LN4 by ciprofloxacin and gemifloxacin are shown in Figure 2. It can be seen that the IC50 values for inhibition of DNA gyrase were at least ten times higher than those required to inhibit topoisomerase IV. These results indicate that, as for all other quinolones, topoisomerase IV is the primary target for gemifloxacin in S. pneumoniae. Data for all quinolones against DNA gyrase and topoisomerase IV from all three pneumococci are summarized in Table II. These data show that gemifloxacin was the strongest inhibitor of topoisomerase IV from the ciprofloxacin-sensitive pneumococcus and from the two ciprofloxacin-resistant strains. All the quinolones, except ciprofloxacin, showed very similar IC50 values against DNA gyrase from S. pneumo!

Stella Rowlands, Leanne Stone, Helen Woolls1 Coast & Coola Health Service District, Nambour NT, Australia As part of the Cancer Care Coordinator's Project Plan, September 2005, Nambour General Hospital a target of "Patients attending Oncology Outpatients will understand what may happen to them during active treatment" was set. A literature review was undertaken; the existing process was reviewed, including a survey of nursing staff on patient education, and criteria audit on patient education documentation. Issues identified in relation to the process were a lack of documented guidelines on patient education and thus is could not be guaranteed that each patient was provided with comprehensive evidence based education. There was no set standard of written information provided to patients. Current documentation on patient education was limited to a brief narrative describing the education and a series of tick boxes in relation to side effects of the drug therapy. There was no formal evaluation to determine whether the patient understood what may happen to them. The checklist was based on checklists used at the Royal Brisbane & Women's Hospital and the Nepean Cancer Care Centre. Input was sought from allied health and nursing staff. It was anticipated that the Checklist would be used in collaboration with the guideline would assist RN's to ensure education was provided in a structured form, delivering a high standard of verbal and written information which was evidence based. Implementation was followed by a criteria audit of the Chemotherapy Education Checklist and a nursing staff survey. Variations to checklist and guideline were made. The Chemotherapy Education Checklist and Guideline has improved the standardisation of chemotherapy education sessions regardless of the nurse delivery. It also ensures areas of education not addressed at the initial education session are followed up at subsequent patient interactions and ginkgo.

Room B, Convention Hall Presiding: Earl 0. Wright. Executive qualities. Perrin Stryker. The Administrative Application of Community Power Structure to Public Health Programs. Cecil G. Shops, M.D. Discussion.

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