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Table 2. Discriminative serum concentrations of extracellular matrix components and of aspartate aminotransferase alone or associated with laminin values for the identification of fibrosis in patients with non-alcoholic fatty liver disease. SEN Laminin 282 ng ml ; Type IV collagen 145 ng ml ; Hyaluronan 24.6 ng ml ; AST 44 IU l ; Laminin + hyaluronan Laminin + type IV collagen Laminin + AST 82 64 82 PPV 82 78 60 NPV 89 81 87 Accuracy 87 80 73.

1. Clark JM, Brancati FL & Diehl 2002 ; . Nonalcoholic fatty liver disease. Gastroenterology, 122: 1649-1657. 2. Yu AS & Keeffe EB 2002 ; . Nonalcoholic fatty liver disease. Reviews in Gastroenterological Disorders, 2: 11-19. 3. Teli MR, James OFW, Burt AD, Bennett MK & Day CP 1995 ; . The natural history of nonalcoholic fatty liver: A follow-up study. Hepatology, 22: 1714-1719. 4. Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC & McCullough AJ 1999 ; . Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology, 116: 14131419. 5. Younossi ZM, Gramlich T, Liu YC, Matteoni C, Petrelli M, Goldblum J & Rybicki L 1998 ; . Nonalcoholic fatty liver disease: assessment of variability in pathologic interpretations. Modern Pathology, 11: 560-565. 6. Falck-Ytter Y, McCullough AJ, Younossi ZM & Marchesini G 2001 ; . Clinical features and natural history of nonalcoholic steatosis syndromes. Seminars in Liver Disease, 21: 17-26. 7. Angulo P, Keach JC, Batts KP & Lindor KD 1999 ; . Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology, 30: 1356-1362. 8. Neuschwander-Tetri BA 2002 ; . Evolving pathophysiologic concepts in nonalcoholic steatohepatitis. Liver, 4: 31-36. 9. Garcia-Tsao G & Boyer JL 1993 ; . Outpatient liver biopsy: how safe is it? Annals of Internal Medicine, 118: 150-153. 10. Luo R, Yang S, Xie J, Zhao Z, He Y & Yao J 2001 ; . Diagnostic value of five serum markers for liver fibrosis. Zhonghua Ganzangbing Zazhi, 9: 148-150. 11. Gibson PR, Fraser JRE, Brown TJ, Finch CF & Jones PA 1992 ; . Hemodynamic and liver function predictors of serum hyaluronan in alcoholic liver disease. Hepatology, 15: 1054-1059. 12. Niemel O, Risteli J, Blake JE, Risteli L, Compton KV & Orrego H 1990 ; . Markers of fibrogenesis and basement membrane formation in alcoholic liver disease. Relation to severity, presence of hepatitis and alcohol intake. Gastroenterology, 98: 1612-1619. 13. Kondo M, Miszputen S, Leite-Mor MMB & Parise ER 1995 ; . The predictive value of serum laminin for the risk of variceal bleeding related to portal pressure levels. Hepatogastroenterology, 42: 542545. Hardingham TE & Adams P 1976 ; . A method for the determination of hyaluronate in presence of other glycosaminoglycans and its application to human intervertebral disc. Biochemical Journal, 159: 143-147. Martins JRM, Passerotti CC, Maciel RMB, Sampaio LO, Dietrich CP & Nader HBN 2003 ; . Practical determination of hyaluronan by a new noncompetitive fluorescence-based assay on serum of normal and cirrhotic patients. Analytical Biochemistry, 319: 65-72. Lee RG 1989 ; . Nonalcoholic steatohepatitis: a study of 49 patients. Human Pathology, 20: 594-598. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA & Bacon BR 1999 ; . Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. American Journal of Gastroenterology, 94: 2467-2474. Dixon JB, Bhathal PS & O'Brien PE 2001 ; . Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology, 121: 91-100. Ratziu V, Giral P, Charlotte F, Bruckert E, Thibault V, Theodorou I, Khalil L, Turpin G & Opolon P 2000 ; . Liver fibrosis in overweight patients. Gastroenterology, 118: 1117-1123. Zweig MH & Campbell G 1993 ; . Receiver-operating characteristics ROC ; plots: a fundamental evaluation tool in clinical medicine review ; . Clinical Chemistry, 39: 561-577. Glantz AG 1992 ; . Primer of Bio-Statistics. 4th edn. McGraw-Hill, Inc., New York. Takamatsu S, Nakabayashi H, Okamoto Y & Nakano H 1997 ; . Noninvasive determination of liver collagen content in chronic hepatitis. Multivariate regression modeling with blood chemical parameters as variables. Journal of Gastroenterology, 32: 355-360. Andersen T, Christoffersen P & Gluud C 1984 ; . The liver in consecutive patients with morbid obesity: a clinical, morphological, and biochemical study. International Journal of Obesity, 8: 107-115. Hautekeete ML, Degott C & Benhamou JP 1990 ; . Microvesicular.

Agreement "CIA" ; with the OIG of the United States Department of Health and Human Services "to promote compliance . with the statutes, regulations and written directives of Medicare, Medicaid and all other federal health care programs as defined in 42 U.S.C. 1320a7b f " "Federal Health Care Program Requirements" ; . Contemporaneously, AstraZeneca.

For purposes of this limitation, the term transplant includes a ventricular assist device VAD ; when used as a bridge to a heart transplant for a patient who is suffering from severe congestive heart failure, is in imminent risk of dying before a heart is available, and has been approved as a heart transplant candidate. In addition, in treatment of cancer, the term transplant includes any chemotherapy and related course of treatment which the transplant supports. For purposes of this limitation, the term transplant does not include transplant of blood or blood derivatives except hematopoietic stem cells ; , or cornea. These services are considered as nontransplantrelated and are covered elsewhere in the contract. Donor costs means all costs, direct and indirect including program administration costs ; , incurred in connection with: medical services required to remove the organ or tissue from either the donor's or the self-donor's body; preserving it; and transporting it to the site where the transplant is performed and hydralazine. We studied the expression of hyaluronan binding proteins HABPs ; during the development of embryonic chick joints, using immunocytochemistry and biotinylated HA. The expression of actin capping proteins and of actin itself was also studied because the cytoskeleton is important in controlling HAHABP interactions. Three cell surface HABPs were localized in the epiphyseal cartilage, articular fibrocartilage, and interzone that comprise the developing joint. Of these three HABPs, CD44 was associated with the articular fibrocartilages and interzone, whereas RHAMM and the IVd4 epitope were associated with all three tissues. Biotinylated HA was localized to interzone and articular fibrocartilages before cavity formation and within epiphyseal chondrocytes post cavitation. Actin filament bundles were observed at the developing joint line, as was the expression of the actin capping protein moesin. Manipulation of joint cavity development, using oligosaccharides of HA, disrupted joint formation and was associated with decreases in CD44 and actin filament expression as well as decreased hyaluronan synthetic capability. These results suggest that HA is actively bound by CD44 at the developing joint line and that HAHABP interactions play a major role in the initial separation events occurring during joint formation.

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