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Author s ; : M. Brochu Affiliation: Dept. of Mining, Metals & Mater. Eng., McGill Univ., Montreal, Que., Canada ; , M.D. Pugh, R.A.L. Drew Journal: Mater. Sci. Eng. A, Struct. Mater., Prop. Microstruct. Process. Switzerland ; , vol.A374, no.1-2, p.34-42 15 June 2004 ; Publisher: Elsevier, Switzerland Language: English ISSN: 0921-5093, Full text Document type: Journal article Abstract: The aim of this study was to join silicon nitride ceramic using a Cu-Ti bi-metallic composite powder. The microstructure and mechanical properties obtained were similar to results obtained with conventional active brazing alloys but with different kinetics. The experimental results obtained show the potential in using the composite powder as a brazing alloy. The reaction layer produced at the ceramic filler metal interface was composed mainly of TiN and Ti5Si3. Similar to many active ceramic brazing processes, the reaction layer was formed in two stages, where the initial step was controlled by a liquid solid reaction, followed by diffusion controlled growth. Depending on the brazing parameter, the reaction layer thickness ranged between 4 and 12 m. Reaction layer growth was modeled and the effective activation energy was found to be 64 mole. The four-point bending strength varied between 250 and 400 MPa, depending on joining conditions. The crack propagation mode was through the interface for low strength joints and through the ceramic for high strength joints 15 refs. ; Inspec No.: 8186477. DepED. He claimed that these textbooks which were covered in the Textbook Count 4 monitoring ; have around 150 errors. The G-Watch Team explained to the group the gravity of the problem not only because of the negative public opinion it might likely cause, but also due to the fact that this transpired even after the DepED instituted a rigid and tedious process of textbook content evaluation, which the textbooks in question went through. The said process, the DepED's Four-Level Textbook Content Evaluation, was instituted in 2004 to precisely address the problem of errors in textbook content. DepED reported that based on their findings, the errors found in the books were only "minor errors." At that time, all the books in question have already been printed. To correct the errors, DepED decided to print a booklet containing corrections to the errors found in the books. As a result of the discussion on errors in textbook content, the CSOs agreed to: o ask the DepED to conduct a Systems Review which should pinpoint the flaws and gaps in the Four-Level Textbook Content Evaluation; o conduct an independent citizen's textbook review for the textbooks already released and are being used at present, ; and based on its results, award citizen's seal of approval or categorize the textbooks into "hall of fame" or "hall of shame; " o organize qualified volunteers who will be part of the evaluation process; o propose to DepED the following: add an "accountability clause" in the contracts of the evaluators to make them liable for textbook errors; institute transparency mechanisms through citizens' participation in the selection and training of evaluators; and include in the bidding documents minimum requirement for authors of the book. After the discussion on textbook content, G-Watch shared to the CSOs in the meeting the reports it had received about undistributed elementary textbooks, which were validated by some of the participants, in particular the teachers, who are members of the PS-LINK. As a response, G-Watch shared its plan to launch the Textbook Walk. The lack of monitors at the ground level was also raised. GWatch explained that this may be due to changes in the delivery schedule.

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Founded as a Benedictine abbey round 1063 by William the Conqueror. Its abbey church Open by appointment year round. SAT SUN and BH, tours at dating from the 11th and 13th C is one of the largest religious buildings in Normandy and 09.30 11.00 14.30 Closed 01 and 25 12. now houses the Htel de Ville Town Hall ; Tours in F GB upon request ; last 1h15 Founded in 1062 by Mathilde de Flanders, wife of William the Conqueror, the Romanesque church still houses Mathilde's tomb stone. Part of the building now houses the Regional Council for Lower Normandy. Listed building built over several centuries and boasting fine organ Considered by Henri IV as "the most beautiful chapel in the kingdom of France", this magnificent building is a fine example of flamboyant gothic style. Masterpiece of Romanesque art, this Benedictine abbey was founded in the 6th C. Abbey church dates from same period and houses a permanent exhibition about the Roman period in Lower Normandy. Neo-gothic dating from the 19th C, built on edge of Rno-Valdieu forest and pemetrexed.

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Tailored to individual needs, the service can encompass auditing, risk assessments, workplace dust and noise monitoring, chairing meetings and establishing action plans and targets. FIRA's Fit for Business manager Alun Watkins explains: "Many companies struggle to allocate adequate resources for a dedicated inhouse health & safety or environmental manager, increasingly a prerequisite in complying with the growing regulatory burden and the huge volume of paperwork involved. Outsourcing the work to FIRA with its team of highly qualified experts can take the strain and be a highly cost effective solution." The new service complements FIRA's existing. Debbie Hazlett, of White Rock, is an extraordinary wife, mom and volunteer. Diagnosed with MS five years ago she has also made a tremendous impact on the annual Super Cities WALK for MS. As chair of last year's White Rock Walk Committee she steered this site to a 38% increase in funds raised. But she insists it was a team effort. "I have MS, and it's important to me that we raise money to find a cure and to help raise money for people with MS, " she explains. Leading by example, last year she recruited a team of 53 friends and family members to her TeamMS "The Hazes" who went on to raise , 059 and become one of the top fundraising teams in BC. Debbie feels she is very lucky to have such a large group of friends and family who support her, especially her husband Alex, and looks forward to recruiting even more TeamMS members to this year's "The Hazes" team. She is also grateful to the MS Society and the role they play providing programs and services for those with MS and raising funds to support research to find a cure. "When I was diagnosed with MS I was overwhelmed, scared and didn't know what to do. My doctor told me to contact the MS Society where I received both information and support to help me cope, " says Debbie. Debbie now gives back to the MS Society in more ways than one. While she is a donor herself and an incredible fundraiser, she also sits on the Lower Mainland Chapter Board, is a peer support counselor and self-help group facilitator. In recognition of the tremendous impact Debbie Hazlett has made to the MS Society of Canada, she was this year's award recipient of the Member, Division Award of Merit. Congratulations Debbie and thanks for your tremendous TeamMS spirit. We know that "The Hazes" will be out in full force on April 9 in White Rock cheering you on as you lead the fight against MS and penicillamine.

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ECRI`s search of the N ational Guid eline Clearinghouse N GC ; id entified four evid ence-based practice guid elines related to d iagnosis and treatm ent of ind ivid uals w ith eating d isord ers: APA is planning to release a third ed ition of their guid eline report titled Practice Guid eline for the Treatm ent of Eating Disord ers. Like the second ed ition of the practice guid eline, w hich w as originally published in 2000, 217 ; the objective of the upd ated ed ition is to provid e psychiatrists w ith help in assessing, m anaging, and treating patients d iagnosed w ith eating d isord ers. 218 ; ECRI received an ad vanced d raft of the guid eline this spring. Accord ing to the draft, the guid eline w ill consid er a num ber of treatm ent options for bulim ia nervosa includ ing psychosocial treatm ents, m ed ications, and com binations of p sychosocial and m ed ication treatm ent. The clin ical recom m end ations w ill be based on available evid ence and clinical consensu s. 219 ; N ICE, in 2004 published Core Interventions in the Treatm ent and Managem ent of Anorexia N ervosa, Bulim ia N ervosa, and Related Eating Disord ers. 199 ; This guid eline m ad e recom m end ations for the id entification, treatm ent, and m anagem ent of eating d isord ers. The role of specific p sychological interventions, pharm acologic agents, and service d elivery system s and service-level interventions w ere evaluated . The inform ation gathered from these evaluations w as integrated and d issem inated to provid e best practice ad vice to clinicians. The scope of the guid eline includ ed a num ber of psychological and p harm acologic interventions for treating bulim ia nervosa. We provid e a d etailed assessm ent of the evid ence used in the report and the conclusions d raw n from that evid ence in Section 3 of our report. The Finnish Med ical Society published guid elines entitled Eating Disord ers ong Child ren and Ad olescents in 2004. 220 ; The stated objectives of these guid elines w ere sim ilar to those of the N ICE report: to collect, sum m arize, and u pd ate the core clinical know led ge im portant for general practice to treat eatin g d isord ers. The authors of this report consid ered the evid ence for d iagnosis, evaluation, m anagem ent , and treatm ent of bulim ia nervosa. The evid ence base for the guid elines in this report cam e from the Cochrane Database of System atic Review s and the Database of Abstracts of Review s of Effectiveness DARE ; . The follow ing outcom es w ere consid ered : 1 ; eating d isord er sym ptom atology, 2 ; rem ission rates, and 3 ; efficacy of treatm ent at red ucing sym ptom s of eating d isord ers and im proving prognosis. In 2003, the erican Acad em y of Ped iatrics published Id entifying and Treating Eating Disord ers. 221 ; The objective of this guid eline report w as to assist ped iatricians w ith early d etection and appropriate m anagem ent of eating d isord ers, and 2 ; prevent the physical and p sychological consequences of malnutrition that allow for progression to a later stage of an eating d isord er. Like other guid elines for eating d isord ers, this report consid ered a range of treatm ent options. H owever, since this guid eline report em phasized early d etection, it also consid ered initial evaluations, physical exam s, and laboratory tests used to screen for eating d isord ers and pentamidine.

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Estimated 2.7 million cases per year 95% of children infected by 5 years of age The most severe disease occurs among children 3-24 months of age Highest incidence among children 3 to 35 months of age Responsible for 5%-10% of all gastroenteritis episodes in children younger than 5 years of age.

Sprycel 20 mg, 50 mg, 70 mg dasatinib monohydrate ; is a new oral tablet available from Bristol-Myers Squibb Canada indicated for the treatment of adult patients with chronic myeloid leukemia CML ; who are resistant or intolerant to prior therapy including imatinib mesylate Gleevec ; . The recommended adult dosage for Sprycel is 70 mg twice daily 140 mg day ; . However, recent data has shown that a 100 mg daily dose provides a more favorable side effect profile while maintaining comparable efficacy. Generally, treatment is continued long-term unless there is evidence of disease progression or the drug becomes no longer tolerated by the patient. Currently, it is estimated that about 3, 000 Canadians are living with CML and that 30% of patients are over 60 years of age. Possible treatment options include conventional chemotherapy, interferons, bone marrow transplant, Gleevec, and now Sprycel. One-quarter to one-third of patients will undergo bone marrow transplants only definitive CML cure ; while those ineligible will typically begin Gleevec therapy. If patients develop resistance to Gleevec, its dose may be increased up to a maximum of 800 mg day, or the drug can be discontinued and another treatment modality chosen, such as Sprycel. For a standard daily dose of 140 mg day and the lower dose of 100 mg day, Sprycel is priced at 0.94 and 6.86 per day, respectively. The daily cost for Gleevec ranges from 7.96 to 5.92 based on a dosage range of 400-800 mg day. Sprycel, therefore, offers a cost saving advantage over high-dose Gleevec. Due to this price difference, the low number of patients being treated, and the fact that Sprycel is considered a second line therapy, this drug should have minimal impact to private payers. Somatuline Autogel 60 mg 0.3 mL, 90 mg 0.3 mL, and 120 mg 0.3 mL lanreotide acetate ; is a long acting formulation of lanreotide, a somatostatin analogue, used for the treatment of acromegaly excessive growth hormone secretion ; . Somatuline Autogel is available as an injection from Ipsen Limited and is administered under the skin every 28 days at doses of 60 mg, 90 mg and 120 mg. Acromegaly is a chronic condition that affects approximately 3-4 people per million. Treatment strategies include surgery, medications, or radiation. Recommended first line agents are the somatostatin analogues octreotide Sandostatin, Sandostatin LAR and generics ; and lanreotide Somatuline Autogel ; . Dopamine agonists are considered second line or are used as adjunctive therapy, and pegvisomant Somavert ; is recommended for those patients who have failed therapy with the other agents mentioned. Pricing has now become available for Somatuline Autogel and ranges from , 102 for 60 mg to , 840 for 120 mg. Based on a 28 day dosing schedule, the annual cost will be approximately , 000 to , 000 per patient. Somatuline Autogel's main comparator, octreotide LAR Sandostatin LAR ; , is also administered once a month and has an annual cost of , 000 to , 000 per patient. Somatuline Autogel, therefore, is within the price range for other comparators within the somatostatin analogues class. Both agents are equally effective at treating acromegaly and Somatuline Autogel should have a minimal impact on private plans and pentasa.

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