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Pregnancy pregnancy category b there was no fetotoxicity or teratogenicity in rats treated with up to 5 mg kg day of torsemide on a mg kg basis, this is 15 times a human dose of 20 mg day; on a mg m 2 basis, the animal dose is 10 times the human dose ; , or in rabbits, treated with 6 mg kg day on a mg kg basis, 5 times the human dose of 20 mg kg day; on a mg m 2 basis, 7 times this dose.
Bumetanide, furosemide, and torsemide are most commonly used.
Have not been researched to determine the optimal safe and therapeutic dosage. 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Table 1 reactions possibly or probably drug-related united states placebo-controlled studies incidence percentages of patients ; the daily doses of torsemide used in these trials ranged from 25 mg to 20 mg, with most patients receiving 5 mg to 10 mg; the duration of treatment ranged from 1 to 52 days, with a median of 41 days and tranylcypromine. Torsemide is also sometimes prescribed to help control high blood pressure. Results: following diuresis, maximum plasma concentration increased from 1 0 ± 0 μ g ml to 1 ± 8 with torsemide p < 05 ; and from 1 ± 5 to 9 ± 9 with furosemide p 16 and treprostinil. The sustained release oral dosage forms of the present invention can be manufactured as a suitable tablet or multiparticulate formulation utilizing procedures known to those skilled in the art which can be modified such that the dosage form provides for the release of the torsemide or pharmaceutically acceptable salt thereof over about 12 to about 24 hours when exposed to an environmental fluid. In this study, patients n 1377 ; with nyha class ii-iii chf received diuretic therapy with torsemide 10 mg or frusemide 40 mg or other diuretics in addition to their existing standard chf therapy for 12 months and triac.

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