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Vaniqa is a prescription drug for external use only. Contractile power that it frequently tears the umbrella cells apart by violent contractions when irritated. While floating about freely these mesenchyme cells do not contract, so far as could be observed, but as soon as they begin to form processes they can be seen to contract. Occasionally two cells anastomose with each other before becoming attached to the wall of the pilidium. In such a case they contract irregularly at first, the intervals between contractions being unequal, but later the contractions become rhythmical and very closely resemble those of the opisthobranch gastropods just described. Three or four con tractions occur in rapid succession and are followed by a comparatively long rest. After the cell branches become fastened to the pilidium wall these rhythmical pulsations cease. The mesenchyme cells now become regular muscles of the larva and contract only when stimulated from the central nervous system. We are witnessing here, then, the passage from an automatic condition, in which the cells contract quite independently from the rest of the larva, into a condition in which every contraction is definitely correlated with that of the other larval muscles. In this nemertean larva the intense contractions resulting in a corkscrew shortening of the branches and fibers occurred subsequent to the fixation of the cells. It was not noticed in any of the free cells even when two of them anastomosed before becoming attached, and all the conditions appeared as favorable as in the veliger larvae. After attachment such a shortening is very noticeable, especially in the apical muscle and the fine radial muscles of the side lappets. In an examination.

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